Chemistry Talk

Guest

The TV news shone a spotlight on Alzheimers yesterday by saying there
are two different
molecules of beta amyloid in the disease. One molecule is very small
and short compared to
the other beta amyloid. And those afflicted by the disease seem to be
flooded with the small
short variety. I tried looking up this new research but was unable to
find it.

I have a question about this finding. Can mercury metal make beta
amyloid shrink in size?
Can fluoride or mercury-fluoride make beta amyloid shrink?

Now this idea that the disease is of a different type of the molecule
from a normal person
is intriguing to apply to the other metal diseases such as Prion. In
Prion disease the prion
protein is well known to have many different types and whether the
most damaging prion
disease is the smallest prion molecule is a question. Now in
Parkinson's disease, the
protein involved there does not seem to come in two types where the
smallest is the
most damaging.

Here I have to ask whether mercury compounds can cause protein
shrinkage?

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies

Guest

Bob wrote:

Bob · Guest

On Tue, 24 Jun 2008 23:16:19 -0700 (PDT),
plutonium.archimedes@gmail.com wrote:

Guest

I am glad Bob brought up secretase for it replaces the word "scissors"
although scissors is
so much more functional of a term.

I looked up secretase to see if a structure was available and
Wikipedia has a picture:
--- quoting Wikipedia on secretase ---
The structure of the three secretases varies widely.

* The á-secretase gene has not been conclusively identified but is
believed to be a metalloproteinase.

* BACE is a transmembrane protein with an extracellular aspartic
acid protease domain.

* ã-secretase is actually a protein complex containing presenilin,
nicastrin, ACH-1, and PEN-2. Presenilin is believed to harbor the
protease domain and represents an important example of a rare type of
protease that cleaves targets within the cell membrane.

--- end quoting ---

Doing some searching around, I find the metalloproteinase has a zinc
ion backbone.

Now I wonder how mercury or mercury compounds such as mercury-fluoride
reacts with
a metalloproteinase with its zinc ion? Would mercury alter the
configuration of the secretase or
and would it alter some of the hydrogen bonds?

What exactly would mercury do to these secretases? I reckon that the
mercury would act
as some form of catalyst where it corrupts many of the secretase
molecules.

Now some people are going to say that mercury of thimerosal, the
mercury preservative
used in vaccines for infants and is speculated to be the blame and
cause of Autism. But one
must also bear in mind that with Global Warming and the huge amount of
mercury thrown
into the air we breathe, all around the world by coal fired power
stations emits a huge amount
of particle mercury. So that the mercury in coal plants in China float
around the world in the
air and a danger not only to the Chinese nearby but float around the
world that people in the
USA can end up breathing mercury produced half way round the world. So
my point is that
although thimerosal mercury was discontinued, the pervading fact of
the world situation is that
mercury in the air that we breathe has been steadily rising and
increasing ever since the 20th
century and it would be instructive for someone to run a statistical
analysis of the amount of
mercury in the air from 1950 on to 2008 correlated with the rise in
the incidents of
these five diseases of Autism, Alzheimers, Prion, Parkinsons, and
Schizophrenia.

The mercury polluted air that humanity has been breathing from 1950
onwards, I bet is a direct
correlation with the increase of those 5 diseases. A case in point is
that in the USA alone
that the incidents of those 5 diseases are the highest in the most
mercury laden air of the
states of Utah and Texas.

Not only do we have Global Warming from all the dirt we put in the
air, but we have Global
Mercury Pollution, where the coal plants in China can affect the
people in the USA and where
the coal plants in the USA can affect the health of people in China.

It does no good for the people in the USA dept of health to proclaim
that Thimerosal was safe
since there is no person in this world that can ever say "mercury is
safe" no matter in what
dosage. Mercury is a poison, and no scientist in this world should
ever side with an outfit
that says mercury is safe. They should be instantly stripped of their
science credentials.
No person, especially infants should have ever been subjected to
mercury.

And as for those who claim that when Thimerosal was discontinued yet
the rise of Autism
continued, well, they do not realize that the rise of mercury in the
air we breathe has risen
unabated for the past 50 years or more.

What the USA dept of health should be doing instead of defending their
indefensible thimerosal
is to measure how much mercury is in the air we breathe. There is a
lack of study and research
as to the amount of mercury in the air we breathe. Some have measured
the air mercury
near coal power plants but the USA should have measured the mercury
throughout the USA.

Now I keep harping about mercury fluoride because I have personally
seen some Alzheimers
cases and I know they drank fluoride water throughout there lives. The
rising presence of
so much fluoride in the water parallels the rise in these five
diseases. So I think there maybe
some connection with fluoride and mercury and these 5 diseases.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies

Archimedes Plutonium · Guest

plutonium.archimedes@gmail.com wrote:
(snipped)

Guest

Bob wrote:
(snip)

Guest

plutonium.archime...@gmail.com wrote:

Bob · Guest

On Tue, 24 Jun 2008 23:16:19 -0700 (PDT),
plutonium.archimedes@gmail.com wrote:

Guest

I notice there is a nice grouping of these 5 diseases as per age of
attack:
Autism in infants before age 10
Schizophrenia in boys as teenagers and girls in 20s
Alzheimers Parkinsons Prion in old age

So we have almost every age group represented except for maybe 30s to
50s.

So does the age grouping match the idea of mercury poisoning? I would
say so, because
mercury can be an accumulative affect and so most are old age
diseases. And as for
Autism, a large dosage of mercury can damage brain sheaths from
developing.

Now I spent a long time considering different compounds of mercury to
explain the different
5 diseases, so that say prion was mercury cesium whereas Alzheimers
was mercury fluoride.
That may have been the wrong approach. Perhaps a better approach would
have been to
focus on the metal ions in the proteins under attack in the disease,
or to focus on what
metals the proteins bind. In Alzheimers, instead of wondering what the
mercury compound
is such as mercury rubidium, instead, focus on what metal ions
constitute the APP scissors
and the protein that is cut. If zinc ions are involved in Parkinsons
alpha synuclein and zinc and
copper in amyloids of Alzheimers and copper and manganese for Prion
proteins. Then I should
not worry so much as what form of mercury is involved, for the concern
is that mercury acts
differently on zinc ions than on copper ions.

So if the reaction of mercury to copper ions is different than the
reaction of mercury on zinc ions
then we can explain why prion disease is different than Alzheimers
disease, for the one is mercury
attacking the zinc ions in Alzheimers and mercury attacking the copper
ions in Prion. Whereas before
I was focused on mercury-cesium versus mercury-fluoride as the
difference between prion and
Alzheimers. In the end, it may well be both the type of mercury and
the type of metal ion in the
protein.

One other note is that there has never been a case where a person
contracted any two or three
of the three old age diseases of Parkinsons, Prion and Alzheimers. I
know of no case where a person had say Parkinsons and then
also had Alzheimers. Now this may or may not support this theory of
mercury as the cause, because
one would think that if mercury is the poison cause that in some
people the mercury would set up two
or more of these diseases simultaneously. And perhaps even see cases
of Autistic children starting to
have Alzheimers or Parkinsons. Now maybe there are such cases but have
not been reported. And
maybe there are many such cases but one of the diseases takes over and
masks the presence of
the other disease and noone bothered to autopsy for 2 or more diseases
simultaneously.

Now in the case of Schizophrenia we have dopamine blockage and perhaps
zinc ions as substitute
for dopamine. So Schizophrenia is much similar to Parkinsons in that
dopamine is reduced. And where
Prion and Alzheimers are very much alike in the fact that a protein
garbage dump is set up in the
brain which kills. So in Autism, Schizophrenia and Parkinsons we have
things "missing in the brain"
whereas in Prion and Alzheimers we have garbage accumulation
strangulation.

So the mercury maybe all the same in all these 5 diseases where it
could be ethyl mercury. But
I rather suspect it is mercury compounds that facilates the onslaught
of these 5 different diseases.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies

Guest

Archimedes Plutonium wrote:

Guest

Bob wrote:

Bob · Guest

On Thu, 26 Jun 2008 22:34:05 -0700 (PDT),
plutonium.archimedes@gmail.com wrote:

Guest

Bob wrote:
(snipped)

Bob · Guest

On Sun, 29 Jun 2008 23:03:58 -0700 (PDT),
plutonium.archimedes@gmail.com wrote:

Guest

On page 359 of Introduction to Genetic Analysis, by Griffiths, Miller,
Suzuki, Lewontin, Gelbart, 1996
is a page that shows a picture of the normal PrP and then a picture of
what happens to turn that
normal PrP into scrapie disease.

The normal PrP has two helices, but in the diseased form, those two
helices have been changed
into 4 beta sheets as the picture in the textbook shows.

Now, the theory of metal causation as mercury with the likely suspect,
one simply has to ask
some chemistry questions. If we place normal PrP into solution of
several compounds of mercury
does not the mercury when in contact with PrP change 2 helices into 4
beta sheets?

Likewise for Alzheimers disease, although I have no book that shows a
picture of the 3 fragments
of beta-amyloid that the APP secretases (scissors) cuts. But if we had
in solution, normal APP
and normal secretases and then applied some mercury compounds, perhaps
mercury-fluoride,
does not that reaction end up drastically changing the normal APP into
beta sheet fragments
that cause Alzheimers disease?

The similarity is striking in that the endproduct in Prion and the end
product in Alzheimers are proteins
that our bodies cannot remove. They are unremovable as plaques becuase
they were formed by a
poison of mercury and which the animal bodies have not evolved a trash
removal system since these
diseases are the increasing amount of mercury poisons present in
modern day air we breathe.

Chemists who are specialists in the mercury molecules, perhaps can
easily spot how a mercury
compound can alter helices into beta sheets. It must not take much
energy because in the 1990s
with the phony-Prusiner model, the energy to make that alteration was
ascribed not to mercury compounds
but to a look-alike folded PrP molecule. So if a close resembling PrP
was thought to be the culprit
in the 1990s, it had little energy wise difference from the normal
PrP, which suggests that a mercury
compound as the true culprit, would easily substitute as the catalytic
converter of helices into
beta sheets.

So if there is a chemist out there, expert in how mercury acts as a
catalyst in conversion of helices
to beta sheets and takes a look at the normal PrP versus diseased PrP
and takes a look at
normal APP and scissors versus Alzheimer diseased APP and scissors,
that I am quite confident
they can immediately select a mercury compound poison that is the true
culprit of these diseases.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies