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Salting out and logP

 
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PostPosted: Tue May 29, 2007 7:02 am    Post subject: Salting out and logP Reply with quote

I know that you can use salt to decrease the aqueous solubility of
organic solutes, but does it also affect the partition coefficient? I
assume that you would promote solubility in the organic phase as you
decrease the solubility in the aqueous phase, but I haven't found this
explicitly stated anywhere. Can anyone point me to a reference?
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Marvin
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PostPosted: Tue May 29, 2007 7:30 pm    Post subject: Re: Salting out and logP Reply with quote

zero529@yahoo.com wrote:
Quote:
I know that you can use salt to decrease the aqueous solubility of
organic solutes, but does it also affect the partition coefficient? I
assume that you would promote solubility in the organic phase as you
decrease the solubility in the aqueous phase, but I haven't found this
explicitly stated anywhere. Can anyone point me to a reference?

The partition coefficients and distribution coefficient

(http://en.wikipedia.org/wiki/Partition_coefficient#Partition_coefficient_and_log_P)will
change if the solubility of the substance in either solvent
changes.
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